POLYPLOIDY IN MYELODYSPLASTIC SYNDROME - A CASE-REPORT

Authors
MANLEY R COCHRANE J PATTON WN
Citation
R. Manley et al., POLYPLOIDY IN MYELODYSPLASTIC SYNDROME - A CASE-REPORT, Cancer genetics and cytogenetics, 106(2), 1998, pp. 170-172
Citations number
6
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
106
Issue
2
Year of publication
1998
Pages
170 - 172
Database
ISI
SICI code
0165-4608(1998)106:2<170:PIMS-A>2.0.ZU;2-1
Abstract
Structural chromosomal abnormalities are common in myelodysplastic syn dromes (MDSs), and complex abnormalities are known to confer a poor pr ognosis. Polyploidy is rare. We report a patient with MDS in whom 8/15 cells were 77,XYY; 2/15 were 83,XYY, and 5/15 were diploid (46,XY). H e experienced rapid evolution of disease, transforming to terminal acu te leukemia. (C) Elsevier Science Inc., 1998.