The L-arginine-nitric oxide pathway appears to play an important role
in systemic hypertension, progressive renal disease, nephrotoxicity (l
ead poisoning), inflammation and atherosclerosis, interactions of nitr
ic oxide with other systems (renin-angiotensin, endothelins, eicosanoi
ds, cytokines and other regulators of inflammation) have been describe
d. These interactions may be important in disease states. Curr Opin Ne
phrol Hypertens 7:547-550. (C) 1998 Lippincott Williams & Wilkins.