BIRTH OF HEALTHY-CHILDREN AFTER INTRACYTOPLASMIC SPERM INJECTION IN 2COUPLES WITH MALE KARTAGENERS-SYNDROME

Objective: To describe two cases in which intracytoplasmic sperm injec tion (ICSI) was successful for patients with infertility due to Kartag ener's syndrome.Design: Case report. Setting: Private hospital for gyn ecology department of reproductive medicine, and university hospital c enter for andrology. Patient(s): Two couples with primary infertility due to Kartagener's syndrome in the male. Intervention(s): ICSI. Main Outcome Measure(s): Pregnancy and birth after ICSI. Result(s): In both couples, ICSI was successful in the first cycle. The uncomplicated pr egnancies resulted in the birth of three healthy children. One female and male/female twins. Conclusion(s): In couples with infertility due to Kartagener's syndrome in the male, ICSI has proved to be a successf ul therapy resulting in clinically healthy offspring. This knowledge m ay improve our understanding of the involvement of paternally inherite d centrosomes, which nucleate microtubules, in human reproduction. (Fe rtil Steril(R) 1998;70:643-6. (C) 1998 by American Society for Reprodu ctive Medicine.).