Objective: To determine if low doses of estrogen and testosterone can
improve the semen quality in oligospermic men. Design: Prospective, no
nrandomized, noncontrolled, clinical study. Setting: Primary level car
e in private practice. Patient(s): Fourteen physically healthy and and
rogenized oligospermic men were selected for the study. Intervention(s
): Combined low-dose estrogen-testosterone was administered orally for
4 months. Main Outcome Measure(s): Semen parameters. Result(s): Nine
cases (64.2%) showed definite improvement in the semen quality, five c
ases (35.8%) did not show much improvement. The wives of three patient
s (21.4%) became pregnant within 6 months of the initiation of therapy
. Conclusion(s): Low-dose estrogen and testosterone may significantly
improve the semen quality in men with oligospermia. (Fertil Steril(R)
1998;70:780-1. (C) 1998 by American Society for Reproductive Medicine.
).