ROLE OF LOW-DOSE ESTROGEN-TESTOSTERONE COMBINATION THERAPY IN MEN WITH OLIGOSPERMIA

Objective: To determine if low doses of estrogen and testosterone can improve the semen quality in oligospermic men. Design: Prospective, no nrandomized, noncontrolled, clinical study. Setting: Primary level car e in private practice. Patient(s): Fourteen physically healthy and and rogenized oligospermic men were selected for the study. Intervention(s ): Combined low-dose estrogen-testosterone was administered orally for 4 months. Main Outcome Measure(s): Semen parameters. Result(s): Nine cases (64.2%) showed definite improvement in the semen quality, five c ases (35.8%) did not show much improvement. The wives of three patient s (21.4%) became pregnant within 6 months of the initiation of therapy . Conclusion(s): Low-dose estrogen and testosterone may significantly improve the semen quality in men with oligospermia. (Fertil Steril(R) 1998;70:780-1. (C) 1998 by American Society for Reproductive Medicine. ).