ATTENUATION OF VIRULENCE BY DISRUPTION OF THE MYCOBACTERIUM-TUBERCULOSIS ERP GENE

Authors
BERTHET FX LAGRANDERIE M GOUNON P LAURENTWINTER C ENSERGUEIX D CHAVAROT P THOURON F MARANGHI E PELICIC V PORTNOI D MARCHAL G GICQUEL B
Citation
Fx. Berthet et al., ATTENUATION OF VIRULENCE BY DISRUPTION OF THE MYCOBACTERIUM-TUBERCULOSIS ERP GENE, Science, 282(5389), 1998, pp. 759-762
Citations number
22
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
282
Issue
5389
Year of publication
1998
Pages
759 - 762
Database
ISI
SICI code
0036-8075(1998)282:5389<759:AOVBDO>2.0.ZU;2-5
Abstract
The virulence of the mycobacteria that cause tuberculosis depends on t heir ability to multiply in mammalian hosts. Disruption of the bacteri al erp gene, which encodes the exported repetitive protein, impaired m ultiplication of M. tuberculosis and M, bovis Bacille Calmette-Guerin in cultured macrophages and mice. Reintroduction of erp into the mutan ts restored their ability to multiply. These results indicate that erp contributes to the virulence of M. tuberculosis.