SYNTHESIS OF PROTEIN CONJUGATES OF 2-CARBOXY-L-ARABINITOL 5-PHOSPHATEAND 2-CARBOXY-L-RIBITOL 5-PHOSPHATE

The synthesis of 5-O-[5-(pentanoic acid)]-phosphono-L-erythro-pent-2-u lose 2 was successfully achieved by coupling benzyl 5-hydroxypentanoat e 9b and 1-O-benzyl-L-erythro-pent-2-ulose ethane-1,2-diyl dithioaceta l 13 with the enediol pyrophosphate 18. Compound 2 was coupled to carr ier proteins, porcine thyroglobuline and bovine serum albumin and the conjugates were treated with KCN to give conjugates of the hapten 1, d esigned to raise catalytic antibodies.