CAMPYLOBACTER UPSALIENSIS-ASSOCIATED DIARRHEA IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS

Campylobacter upsaliensis was isolated from the feces of 20 human immu nodeficiency virus (HIV)infected patients with diarrhea over a 67-mont h period, representing 18.5% of fecal Campylobacter isolates from our HIV-seropositive patients. All isolates were recovered from feces by a 0.45-mu m-membrane filtration method. Culture on Skirrow's selective medium incubated at 42 degrees C failed to support any growth. The mea n CD4 cell count of the patient group was 185/mm(3) (range, 0-840/mm(3 )), and all patients had diarrhea for 1-60 days (mean, 19 days). Thirt een had no other enteric pathogen isolated, and three patients (CD4 co unts, less than or equal to 70/mm(3)) had persistent carriage for betw een 5 weeks and 3 months. All tested isolates were susceptible to eryt hromycin and doxycycline, but three isolates from two patients were re sistant to ciprofloxacin. C. upsaliensis is associated with prolonged diarrhea of mild to moderate severity in HIV-infected patients.