CELLULAR EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE FOLLOWING RAT CORTICAL INCISION AND ITS SUPPRESSION BY HYDROXYL RADICAL SCAVENGER, 1,2-BIS(NICOTINAMIDO)PROPANE

Authors
YAMANAKA K KUMURA E YOSHIMINE T MARUNO M TANIGUCHI M KOSAKA H HAYAKAWA T
Citation
K. Yamanaka et al., CELLULAR EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE FOLLOWING RAT CORTICAL INCISION AND ITS SUPPRESSION BY HYDROXYL RADICAL SCAVENGER, 1,2-BIS(NICOTINAMIDO)PROPANE, Neuroscience research, 31(4), 1998, pp. 347-350
Citations number
24
Categorie Soggetti
Neurosciences
Journal title
Neuroscience research → ACNP
ISSN journal
01680102
Volume
31
Issue
4
Year of publication
1998
Pages
347 - 350
Database
ISI
SICI code
0168-0102(1998)31:4<347:CEOINS>2.0.ZU;2-Q
Abstract
Cellular expression of an inducible isoform of nitric oxide synthase ( iNOS) was studied immunohistochemically 1, 3 and 7 days following rat cortical incision. The induction of INOS was demonstrated almost exclu sively in the macrophages accumulated within the incision cavity on da y 3. They were significantly reduced in number by the treatment with 1 ,2-bis(nicotinamido)propane (P < 0.01), suggesting the involvement of hydroxyl radicals in the macrophage activation after cortical injury. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.