NO SUSCEPTIBILITY OF COLON TISSUE IMPLANTED INTO THE GLANDULAR STOMACH OF RATS TO N-NITROSO-N-METHYLUREA CARCINOGENESIS

Authors
ANDO Y UESAKA T KIDO S FUJIMOTO N TATEMATSU M ISHIMURA Y SHIRAKI K HIRATA S KURAMOTO K SHOJI S KATOH O WATANABE H
Citation
Y. Ando et al., NO SUSCEPTIBILITY OF COLON TISSUE IMPLANTED INTO THE GLANDULAR STOMACH OF RATS TO N-NITROSO-N-METHYLUREA CARCINOGENESIS, Oncology Reports, 5(6), 1998, pp. 1373-1376
Citations number
24
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
5
Issue
6
Year of publication
1998
Pages
1373 - 1376
Database
ISI
SICI code
1021-335X(1998)5:6<1373:NSOCTI>2.0.ZU;2-S
Abstract
The present study was undertaken to determine the response of colonic mucose implanted into the stomach fundus in 6-week-old male F344 rats to oral administration of N-nitroso-N-methylurea (MNU). In graft + MNU , 15% animals had tumors in the implanted colon tissue whereas a 26% i ncidence of gastric tumors was observed for the pyloric mucose. In MNU alone, 30% of rats demonstrated gastric tumors. In graft alone 10% of tumors were observed in the grafted site but none in the pylorus. Thu s while graft tissue may intrinsically have an elevated risk of tumor development, no susceptibility to MNU was observed in the present stud y.