LOBULAR CARCINOMA IN-SITU OF THE BREAST - RESULTS OF A RADIOSURGICAL CONSERVATIVE TREATMENT

From 1980 to 1992, 17 women underwent lumpectomy (13) or quadrantectom y (4) and whole breast irradiation (median dose: 52 Gy) for pure lobul ar carcinoma in situ (LCIS). Three cases correspond to palpable lesion s and 14 were discovered only by mammography. Twelve women also receiv ed tamoxifen at 20 mg/day for two years. With a median follow-up of 88 months, no local or regional recurrences have been recorded. The glob al rate of bilateral carcinoma was 17.6% (2 synchronous and one metach ronous). In the literature, only eight other cases of LCIS were treate d by lumpectomy and radiation therapy, but without details and data on long-term results. After biopsy alone for LCIS subsequent infiltratin g ct-cinema occurred in about 15% of the cases. Thus, the classical ra diosurgical association should represent an interesting alternative bo th for biopsy alone and radical surgery until now only proposed to tre at LCIS.