L. Grammer et al., UTILITY OF ANTIBODY IN IDENTIFYING INDIVIDUALS WHO HAVE OR WILL DEVELOP ANHYDRIDE-INDUCED RESPIRATORY-DISEASE, Chest, 114(4), 1998, pp. 1199-1202
Citations number
16
Categorie Soggetti
Respiratory System","Cardiac & Cardiovascular System
Objective: To define the utility of serum antibody against trimellitic
anhydride (TMA) in predicting which individuals employed, at Amoco Co
rporation, in the manufacture of TMA have or will develop immunologica
lly mediated respiratory disease, such as asthma, due to exposure to T
MA. Methods: In 1990 we initiated a clinical and immunologic cross-sec
tional study of 181 subjects exposed to TMA for at least 1 year who ha
d not been diagnosed with an immunologic respiratory disease. We then
clinically and immunologically followed 119 of these subjects for the
next 5 years to determine whether they would develop an immunologic re
spiratory disease due to TMA exposure. Results: Of the 16 individuals
with IgE against TMA conjugated to human serum albumin (TM-HSA) in 199
0, 3 had immediate asthma and another 6 developed asthma during the 5-
year follow-up. Of the 165 individuals without IgE against TM-HSA, non
e had immediate asthma in 1990 and only 1 of 102 individuals followed
for 5 years developed asthma, Of the 44 subjects with IgG against TM-H
SA, 6 had an immunologic respiratory disease in 1990 and 2 more develo
ped it in the ensuing 5 years. Of the 137 subjects without IgG against
TM-HSA, none had an immunologic respiratory disease in 1990 and none
of the 80 subjects followed for 5 years developed it. Conclusions: Dev
elopment of antibody against TM-HSA, both IgE and IgG, is predictive o
f subjects who have or will develop immunologically mediated respirato
ry disease due to TMA exposure, The absence of antibody is a potent ne
gative predictor.