Authors
Citation
St. Cole, COMPARATIVE MYCOBACTERIAL GENOMICS, Current opinion in microbiology, 1(5), 1998, pp. 567-571
Citations number
27
Categorie Soggetti
Microbiology
Journal title
ISSN journal
13695274
Volume
1
Issue
5
Year of publication
1998
Pages
567 - 571
Database
ISI
SICI code
1369-5274(1998)1:5<567:CMG>2.0.ZU;2-6
Abstract
Genomics is providing us with a mass of information about the biochemi
stry, physiology and pathogenesis of Mycobacterium tuberculosis and My
cobacterium leprae. Comparison of the two genome sequences is mutually
enriching and indicates that the M. leprae genome appears to have und
ergone shrinkage and large-scale gene inactivation, which may account
for the exceptionally slow growth of this organism.