SYNTHESIS OF TRITIUM-LABELED BIOLOGICALLY-ACTIVE ANALOGS OF PROGESTERONE BY SELECTIVE HYDROGENATION OF 17-ALPHA-CYCLOHEX-3'-EN-PREGNA-1,4-DIEN-3,20-DIONE

Authors
SHEVCHENKO VP NAGAEV IY POTAPOVA AV MYASOEDOV NF KAMERNITSKY AV LEVINA IS KULIKOVA LE SMIRNOV AN
Citation
Vp. Shevchenko et al., SYNTHESIS OF TRITIUM-LABELED BIOLOGICALLY-ACTIVE ANALOGS OF PROGESTERONE BY SELECTIVE HYDROGENATION OF 17-ALPHA-CYCLOHEX-3'-EN-PREGNA-1,4-DIEN-3,20-DIONE, Journal of labelled compounds & radiopharmaceuticals, 41(10), 1998, pp. 919-925
Citations number
9
Categorie Soggetti
Chemistry Analytical","Chemistry Medicinal","Biochemical Research Methods","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
41
Issue
10
Year of publication
1998
Pages
919 - 925
Database
ISI
SICI code
0362-4803(1998)41:10<919:SOTBAO>2.0.ZU;2-G
Abstract
The procedure of selective hydrogenation with gaseous tritium of 16 al pha,17 alpha-cyclohex-3'-en-pregna-1,4-dien-3,20-dione (St0) has been elaborated, and isotopically labelled 16 alpha,17 alpha-cyclohexanopre gna-1,4-dien-3,20-dione (St1), 16 alpha,17 alpha-cyclohex-3'-en-pregn- 4-en-3,20-dione (St2), 16 alpha,17 alpha-cyclohexanopregn-4-en-3,20-di one (St3) with molar radioactivity of 41, 44, 85 Ci/mmol, respectively , obtained. By hydrogenation with gaseous hydrogen, tritium labelled ( St3) was converted to 16 alpha,17 alpha-cyclohexano-5 alpha-pregnan-3, 20-dione (5 alpha-St4) and 16 alpha,17 alpha-cyclohexano-5 beta-pregna n-3,20-dione (5 beta-St4).