SOLID-STATE ORGANIC-REACTIONS PROCEEDING BY PULVERIZATION - OXIDATIONAND HALOGENATION WITH IODOSOBENZENE AND INORGANIC SOLID-SUPPORTS

Pulverization-activation method was employed to accelerate solid-state organic reactions. Crushing and grinding of solid mixtures of hydroge n halide-treated silica gels, iodosobenzene and organic substrates in the absence of a solvent brought about smooth and rapid reactions to g ive halogenated and/or oxidized products in good yields. Various sulfi des were smoothly converted to sulfonyl chlorides in one step in excel lent yields. The surface of silica gel activated by pulverization serv es as a reaction field on which reagent molecules can effectively enco unter with each other. (C) 1998 Elsevier Science Ltd. All rights reser ved.