EFFECTIVE NUCLEOPHILIC TRIFLUOROMETHYLATION WITH FLUOROFORM AND COMMON BASE

Authors
RUSSELL J ROQUES N
Citation
J. Russell et N. Roques, EFFECTIVE NUCLEOPHILIC TRIFLUOROMETHYLATION WITH FLUOROFORM AND COMMON BASE, Tetrahedron, 54(45), 1998, pp. 13771-13782
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
45
Year of publication
1998
Pages
13771 - 13782
Database
ISI
SICI code
0040-4020(1998)54:45<13771:ENTWFA>2.0.ZU;2-7
Abstract
Common bases (alcoholate, dimsyl anion or amide) are able to deprotona te trifluoromethane to form a trifluoromethyl anion equivalent. In thi s reaction DMF plays a crucial role of stabilisation. Trifluoromethyl aryl alcohols, ketones or sulfides can be obtained in good yields with the new reagent CF3H/Base/DMF. (C) 1998 Elsevier Science Ltd. All rig hts reserved.