Day-to-day variations in diet and physical exercise, large variations
in the glucose response to small changes in insulin doses, and high in
sulin sensitivity are characteristic of preschool children with diabet
es. Hence, difficulties in achieving adequate metabolic control and st
able glycaemia in preschool children are common. In addition, hypoglyc
aemic episodes tend to be frequent and severe in this age group. Probl
ems identifying and treating hypoglycaemia present an additional chall
enge for the diabetes team and for the family caring for the young chi
ld with diabetes. Specific glucose targets are provided for this age g
roup: premeal levels of 6-12 mmol l(-1) (110-220 mg dl(-1)) with bedti
me levels above 8 mmol l(-1) (140 mg dl(-1)). It is important to note
that children who suffer severe hypoglycaemic events at a young age sh
ow evidence of subtle cognitive deficits when tested during adolescenc
e. The question of whether or not the years before pubertal onset cont
ribute less towards the development of diabetes-related microvascular
complications than do the years starting with the onset of puberty rem
ains controversial. Twice-daily or multiple insulin injections, dietar
y adjustments and considerations, home blood-glucose monitoring, famil
y education, support groups and 24-h hotline information facilities ca
n help to achieve good metabolic control without severe hypoglycaemia
in the preschool child. In general, good metabolic control without sev
ere hypoglycaemia can be achieved using frequent counselling and a car
ing team approach.