COMMUNITY-ACQUIRED LOWER RESPIRATORY-TRACT INFECTIONS - CHOOSING ANTIBIOTICS FOR LOWER RESPIRATORY-TRACT INFECTIONS - PHARMACODYNAMICS

Experimental models: Experimental models have been developed to study the fundamental determinants of antibiotic action: the active compound , the bacteria, the host the infected organ and their characteristic p roperties. The American neutropenic murine model: This model has demon strated that the duration of antibiotic concentrations above the MIC i s a factor predictive of efficacy. When T exceeds the MIC by 40%, ther e is a significant reduction in the inoculum. Unit dose: Also a factor predictive of amoxycillin efficacy. The French model of experimental murine pneumonia: This mode has demonstrated that amoxycillin doses sh ould be increased for pneumococci with decreased susceptibility to pen icillin G..