RADIOIMMUNODETECTION OF RAT AND RABBIT CARTILAGE USING A MONOCLONAL-ANTIBODY SPECIFIC TO LINK PROTEINS

Authors
CASSIEDE P AMEDEE J VUILLEMIN L ROUAIS F BAREILLE R BORDENAVE L BASSECATHALINAT B HARMAND MF DUCASSOU D
Citation
P. Cassiede et al., RADIOIMMUNODETECTION OF RAT AND RABBIT CARTILAGE USING A MONOCLONAL-ANTIBODY SPECIFIC TO LINK PROTEINS, Nuclear medicine and biology, 20(7), 1993, pp. 849-855
Citations number
26
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
20
Issue
7
Year of publication
1993
Pages
849 - 855
Database
ISI
SICI code
0969-8051(1993)20:7<849:RORARC>2.0.ZU;2-S
Abstract
Biodistribution analysis using [I-125]Fab-6F3 specific to link protein s from human articular cartilage performed in rats by autoradiography showed a high concentration of radioactivity in all cartilaginous tiss ues. Preliminary immunoscintigraphic assays were performed in rabbits. Front and side view images of whole animals exhibited high uptake in cartilage tissue of the knee articulation, in the invertebral disk and the humeral head. This fixation was still detected 24 h post-injectio n, although high washout of radioactivity was observed.