EFFECTS OF LID SUTURING AND TRANSSCLERAL CRYOTHERAPY ON OCULAR GROWTHIN A PIGLET MODEL

Purpose. To study whether lid suturing can induce axial myopia and exp lore whether trans-scleral cryotherapy can affect ocular growth in pig lets or not. Methods. A total of fourteen 2- to 3-week-old piglets wer e studied. Three groups were included: lid suture, cryotherapy, and bo th lid suture/cryotherapy groups. The lid suturing group (N = 6) was g iven lid suturing to produce visual deprivation, The cryotherapy group (N = 4) received transcleral cryotherapy 360 degrees to encircle ante rior to the equator. Both treatment groups (N = 4) received both cryot herapy and lid suturing, The cycloplegic refraction, corneal power, bi ometric axial length, and intraocular pressure (IOP) were measured bef ore the experiments and 4 months later, Results. Mild axial myopia was induced in five lid-sutured eyes of the lid suturing group. The ocula r refraction and eye size of cryotherapy eyes were not different from the control eyes in the cryotherapy group, More myopia was found in al l four piglets that received both cryotherapy and lid suturing, Conclu sions. Lid suturing can induce axial myopia; however, cryotherapy did not affect normal eye growth and did not prevent the development of li d suturing myopia in piglets.