Gene transfer is one of the key techniques in gene therapy application
. Unfortunately, it seems that by now, there still exists no approach
with simplicity, easiness, efficiency and safety. A novel method for g
ene delivery, electro-acupuncture needle-mediated gene transfer which
combined the Chinese traditional acupuncture with modern gene introduc
tion, was developed. With acupuncture needle carrying exogenous gene i
nto muscle after direct electronic stimuli, efficient gene delivery wa
s achieved.