THE INFLUENCE OF SELECTION ON STRESS REACTIVITY IN MICE - PART VI - EFFECT OF STARVATION AND T-3 INJECTION ON THE LEVEL OF GLUTATHIONE IN LIVER AND KIDNEY

The studies were carried out on mice selected for a high rate of weigh t gain and on control unselected mice whose parents had been mated ran domly. All animals were 6-weeks-old. Twenty-four-hour starvation and a n injection of 50 and 100 mu g triiodothyronine (T-3) were chosen as m odels of physical and biochemical stress. Starvation caused a decrease in the level of glutathione in the liver and the kidney of both group s. The T-3 injections in both doses and over time periods of 12, 24 an d 36 h caused a high increase of the concentration of GSH in the liver and in the kidney. These differences were much a high higher er in th e selected mice.