FLAVONOIDS AND LIGNANS FROM VIROLA-SURINAMENSIS TWIGS AND THEIR IN-VITRO ACTIVITY AGAINST TRYPANOSOMA-CRUZI

Authors
LOPES NP CHICARO P KATO MJ ALBUQUERQUE S YOSHIDA M
Citation
Np. Lopes et al., FLAVONOIDS AND LIGNANS FROM VIROLA-SURINAMENSIS TWIGS AND THEIR IN-VITRO ACTIVITY AGAINST TRYPANOSOMA-CRUZI, Planta medica, 64(7), 1998, pp. 667-669
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences","Chemistry Medicinal
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
64
Issue
7
Year of publication
1998
Pages
667 - 669
Database
ISI
SICI code
0032-0943(1998)64:7<667:FALFVT>2.0.ZU;2-F
Abstract
Dichloromethane extracts from twigs of Virola surinamensis (Myristicac eae) showed in vitro trypanosomicidal activity against trypomastigote form of Trypanosoma cruzi. The extract, fractionated by preparative ci rcular chromatography and preparative high-performance liquid chromato graphy yielded two steroids, two lignans, five flavonoids, and one pol yketide. Among the isolated compounds, the lignans presented the highe st trypanosomicidal activity.