W. Dabkowski et al., A SIMPLE AND EFFICIENT SYNTHESIS OF NUCLEOTIDES CONTAINING 5'-S-PHOSPHOROTHIOATE OR 3'-S-PHOSPHOROTHIOATE LINKAGE, Nucleosides & nucleotides, 17(9-11), 1998, pp. 1635-1637
A new efficient synthesis procedure leading to the nucleotide containi
ng 5'-S or 3'-S-phosphorothioate linkage will be presented. The tittle
compounds were prepared in the reaction anhydronucleoside with nucleo
side phosphorodithioates. The second way is based on phosphitylation r
eaction using the nucleosidylphosphorofluoridites.