STRONG, SPECIFIC, REVERSIBLE BINDING LIGANDS FOR TRANSFER-RNA - COMPARISON BY FLUORESCENCE AND NMR SPECTROSCOPIES WITH DISTAMYCIN BINDING FOR A NEW STRUCTURAL CLASS OF LIGAND

Authors
BICHENKOVA EV SADATEBRAHIMI SE WILTON AN OTOOLE N MARKS DS DOUGLAS KT
Citation
Ev. Bichenkova et al., STRONG, SPECIFIC, REVERSIBLE BINDING LIGANDS FOR TRANSFER-RNA - COMPARISON BY FLUORESCENCE AND NMR SPECTROSCOPIES WITH DISTAMYCIN BINDING FOR A NEW STRUCTURAL CLASS OF LIGAND, Nucleosides & nucleotides, 17(9-11), 1998, pp. 1651-1665
Citations number
40
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
9-11
Year of publication
1998
Pages
1651 - 1665
Database
ISI
SICI code
0732-8311(1998)17:9-11<1651:SSRBLF>2.0.ZU;2-S
Abstract
Binding data are presented for the interaction with brewer's yeast tRN A(Phe) Of a new structural family of ligands, symmetrical 'bis-benzimi dazoles. In addition specific perturbations in chemical shifts were de tected by 1-dimensional NMR spectroscopy at 400 MHz for some imino and aromatic methyl protons of tRNA(Phe) when the tRNA was titrated with distamycin. Competitive displacement of the benzimidazole by added dis tamycin was followed fluorescence spectroscopy.