STUDIES ON ALTERNATE STRAND TRIPLE-HELIX FORMATION BY OLIGODEOXYRIBONUCLEOTIDES CONTAINING A 3'-3'-PHOSPHODIESTER BOND

Authors
DENAPOLI L GALEONE A MAYOL L MESSERE A MONTESARCHIO D PEPE A PICCIALLI G
Citation
L. Denapoli et al., STUDIES ON ALTERNATE STRAND TRIPLE-HELIX FORMATION BY OLIGODEOXYRIBONUCLEOTIDES CONTAINING A 3'-3'-PHOSPHODIESTER BOND, Nucleosides & nucleotides, 17(9-11), 1998, pp. 1709-1716
Citations number
6
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
9-11
Year of publication
1998
Pages
1709 - 1716
Database
ISI
SICI code
0732-8311(1998)17:9-11<1709:SOASTF>2.0.ZU;2-4
Abstract
ODNs containing a 3'-3' phosphodiester linkage as inversion of polarit y motif have been shown to cooperatively bind to 5'-(purine)(m)(pyrimi dine)(n)-3' type duplexes by specific alternate strand recognition of the adjacent oligopurine domains. An NMR study has been undertaken to investigate the role of the 3'-3' linked nucleosides and their nearest neighbours in the stabilization of the triple helical complexes.