A VERSATILE POLYMER SUPPORT USEFUL FOR LARGE-SCALE SYNTHESIS OF DNA FOR BIOMEDICAL APPLICATIONS

Authors
JAISANKAR P HINZ M HAPP E SELIGER H
Citation
P. Jaisankar et al., A VERSATILE POLYMER SUPPORT USEFUL FOR LARGE-SCALE SYNTHESIS OF DNA FOR BIOMEDICAL APPLICATIONS, Nucleosides & nucleotides, 17(9-11), 1998, pp. 1787-1792
Citations number
7
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
9-11
Year of publication
1998
Pages
1787 - 1792
Database
ISI
SICI code
0732-8311(1998)17:9-11<1787:AVPSUF>2.0.ZU;2-0
Abstract
A suitably derivatized Merckogel(R) 1 as an efficient solid support fo r the large-scale synthesis of DNA for biomedical applications, is des cribed. Partial hydrolysis of these polyvinylacetate resins with 0.5 M NaOH solution(1) at room temperature for 30 - 80 min. yielded carrier s 1 that could be loaded with 120, 150, 258, and 368 mu moles of nucle osides g(-1).