SYNTHESIS OF DERIVATIVES OF 3-METHYLXANTHINE AND 1-METHYL-3-ISOBUTYLXANTHINE 7-BETA-D-RIBOFURANOSIDES

Authors
OZOLA V MAURINSH Y LIDAKA M
Citation
V. Ozola et al., SYNTHESIS OF DERIVATIVES OF 3-METHYLXANTHINE AND 1-METHYL-3-ISOBUTYLXANTHINE 7-BETA-D-RIBOFURANOSIDES, Nucleosides & nucleotides, 17(9-11), 1998, pp. 1983-1986
Citations number
6
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
9-11
Year of publication
1998
Pages
1983 - 1986
Database
ISI
SICI code
0732-8311(1998)17:9-11<1983:SODO3A>2.0.ZU;2-Y
Abstract
Methods of synthesis of yl-beta-D-ribofuranosyl)-8-chloro-3-methylxant hine (5a) and 1-methyl-3-isobutylxanthine (5b) were reported. Further nucleophilic displacement of chlorine has provided the corresponding 8 -alkylamino and 8-benzylamino derivatives (6a,b-9a,b). Several 5'-acyl analogues of 3-methylxanthine-7-beta-D-ribofuranoside (15-18) were sy nthesized using propylidene-beta-D-ribofuranosyl)-3-methylxanthine (10 ) as intermediate.