SPECIAL PROPERTIES OF MODIFICATION OF SSDNA TARGET BY ALKYLATING DERIVATIVES OF OLIGONUCLEOTIDES IN TANDEM COMPLEXES

The influence of an effector (di-N-(2-hydroxyethyl)-phenazinium deriva tive of oligonucleotide) on modification of the DNA target by alkylati ng derivatives of oligonucleotides having various hybridization proper ties was studied. Being adjacent to the alkylating group of the reagen t, the effector enhances the target modification if the oligonucleotid e reagent has low hybridization properties aid suppresses the modifica tion if the reagent can form the stable complex with the DNA target at the used conditions.