We consider a regular singular Sturm-Liouville operator L := - d<SUP>2
</SUP>/dx<SUP>2</SUP> + q(x)/x<SUP>2</SUP>(1 - x)<SUP>2 </SUP>on the l
ine segment [0,1]. We impose certain boundary conditions such that we
obtain a semibounded self-adjoint operator. It is known (cf. Theorem 1
.1 below) that the zeta-function of this operator [GRAPHICS] has a mer
omorphic continuation to the whole complex plane with 0 being a regula
r point. Then, according to [RS] the zeta-regularized determinant of L
is defined by det(zeta)(L) := exp (-zeta'(L,)(0)). In this paper we a
re going to express this determinant in terms of the solutions of the
homogeneous differential equation Ly = 0 generalizing earlier work of
S. LEVIT and U. SMILANSKY [LS], T. DREYFUS and H. DYM [DD], and D. BUR
GHELEA, L. FRIEDLANDER and T. KAPPELER [BFK1, BFK2]. More precisely we
prove the formula det(zeta)(L) = pi W(psi phi)/2(nu)0+(nu)1 Gamma(nu(
0)+1)(nu(1)+1). Here phi, psi is a certain fundamental system of solut
ions for the homogeneous equation Ly = 0, W(phi, psi) denotes their Wr
onski determinant, and nu(0), nu(1) are numbers related to the charact
eristic roots of the regular singular points 0, 1.