SYNTHESIS AND PROPERTIES OF C-AZALYXONUCLEOSIDES

1-beta-(4-Imidazoyl)- and beta-(5-uracilyl)-1,4-dideoxy-1,4-imino-L-ly xitols were synthesized stereoselectively via a sequential procedure b y the addition of the corresponding metal salts of heterocycles, Swern oxidation, reductive aminocyclization, and deprotection. Their struct ures were determined based on X-ray crystallography. From the NMR meas urements of their N-acyl derivatives, two rotational isomers were obse rved. Their bioassay is also described.