Background: Perfluorocarbon liquids (PFCLs) are useful for floating va
rious materials off the posterior retina during vitreoretinal surgery.
It is generally assumed that buoyancy forces restrict this use to obj
ects with specific gravity lower than that of PFCLs. Methods: We teste
d potential intraocular foreign body materials with specific gravities
ranging from 1.1-8.7. The relative affinities of each material for sa
line and PFCL (specific gravity 1.94) were determined. For each materi
al, we then tested the ability of several specimens of increasing surf
ace/volume ratio to float at the saline-PFCL interface in a glass beak
er. Results: All materials with specific gravity higher than PFCL demo
nstrated a greater affinity for saline than for PFCL. Specimens of eac
h of these dense materials floated at the saline-PFCL interface, provi
ded that the surface/volume ratio of the specimen was above a critical
value. The critical surface/volume ratio for each material was direct
ly proportional to its specific gravity. Conclusions: PFCLs may be use
ful for manipulating a variety of intraocular foreign bodies, even tho
se with specific gravities higher than PFCL. Surface forces, in additi
on to buoyancy, govern the disposition of small foreign bodies at the
saline-PFCL interface.