COMPARISON OF ADJUVANTS WITH RESPECT TO SERUM IGG ANTIBODY-RESPONSE IN ORALLY IMMUNIZED CHICKENS

We have previously shown that oral immunization with non-replicating a ntigens hardly induced serum IgG antibody response in chickens and add ition of sodium fluoride (NaF) to the immunogen markedly improved thei r immunological states. In the present study, taurine, lithium and Qui llaja saponin (e-SAP) were compared with NaF with respect to their enh ancement of serum IgG antibody response in chickens after oral immuniz ation. The antibody titer of chickens which received e-SAP as the muco sal adjuvant tended to be higher than that of chickens which received antigen plus NaF. Simultaneous administration of antigen with lithium or taurine elicited a higher antibody titer in chickens compared to th ose of chickens orally immunized with antigen alone, but the effect of these two adjuvants was less efficient compared with that of NaF. The se results suggested that e-SAP as well as NaF is useful as an oral ad juvant for chickens. (C) 1998 Elsevier Science Ltd. All rights reserve d.