THE INFLUENCE OF THE HELP SYSTEM ON YIELD SHEAR-STRESS IN VASCULAR-DISEASE

At a constant haematocrit ratio the yield shear stress (YSS) depends o n the level of fibrinogen and on the influence of other plasma constit uents, erythrocyte membrane changes on the red cells and fibrinogen in teraction. The study of the influence of the H.E.L.P. system on the va lue of YSS was carried out in 9 patients with vascular disease (acute stroke - 3 patients -, multi-infarct dementia - 3 patients -, peripher al arteriosclerotic vascular disease - 2 patients - and coronary heart disease - 1 patient -) in the model of diluted plasma media varying i n fibrinogen concentration. The H.E.L.P. system application significan tly decreased the value of YSS (p<0.001), which was related to the par allel reduction of the fibrinogen level (p<0.001) and plasma viscosity (p<0.001). The significant coefficients of correlations were found ou t between following parameters: YSS and fibrinogen (p<0.001), YSS and plasma viscosity (p<0.001) and fibrinogen and plasma viscosity (p<0.00 1) .