EFFICIENT SYNTHESIS OF SUBSTITUTED OXOPIPERAZINES FROM AMINO-ACIDS

Authors
MOHAMED N BHATT U JUST G
Citation
N. Mohamed et al., EFFICIENT SYNTHESIS OF SUBSTITUTED OXOPIPERAZINES FROM AMINO-ACIDS, Tetrahedron letters, 39(45), 1998, pp. 8213-8216
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
45
Year of publication
1998
Pages
8213 - 8216
Database
ISI
SICI code
0040-4039(1998)39:45<8213:ESOSOF>2.0.ZU;2-V
Abstract
The synthesis of substituted oxopiperazines, which may act as conforma tionally constrained peptide mimics, is reported. The synthesis is bas ed on the cyclization of sulfonamide dipeptides with dibromoethane as the 1, 2-dielectrophile. Alternatively, these mimetics were prepared v ia a Mitsunobu reaction. (C) 1998 Elsevier Science Ltd. All rights res erved.