SYNTHESIS OF ENANTIOMERICALLY PURE 3-AMINO-1,2-DIOLS BY REDUCTIVE AMINATION OF RACEMIC 2,3-DIALKOXYKETONES

Authors
HUTIN P PETIT Y LARCHEVEQUE M
Citation
P. Hutin et al., SYNTHESIS OF ENANTIOMERICALLY PURE 3-AMINO-1,2-DIOLS BY REDUCTIVE AMINATION OF RACEMIC 2,3-DIALKOXYKETONES, Tetrahedron letters, 39(45), 1998, pp. 8277-8280
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
45
Year of publication
1998
Pages
8277 - 8280
Database
ISI
SICI code
0040-4039(1998)39:45<8277:SOEP3B>2.0.ZU;2-M
Abstract
The reductive amination of racemic 2,3-dialkoxyketones by tetrabutylam monium triacetoxyborohydride in the presence of (R) or (S)-alpha-methy lbenzylamine allows the stereocontrolled access to 3-amino-1,2-diols i n high enantiomerical purity via a partial dynamic resolution. (C) 199 8 Published by Elsevier Science Ltd. All rights reserved.