STEREOSELECTIVE IONIC HYDROGENATION OF VINCA ALKALOIDS AND VINORELBINE IN SUPERACIDS - AN ACCESS TO 4'R-REDUCED ANALOGS

Authors
LAFITTE C JOUANNETAUD MP JACQUESY JC FAHY J DUFLOS A
Citation
C. Lafitte et al., STEREOSELECTIVE IONIC HYDROGENATION OF VINCA ALKALOIDS AND VINORELBINE IN SUPERACIDS - AN ACCESS TO 4'R-REDUCED ANALOGS, Tetrahedron letters, 39(45), 1998, pp. 8281-8282
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
45
Year of publication
1998
Pages
8281 - 8282
Database
ISI
SICI code
0040-4039(1998)39:45<8281:SIHOVA>2.0.ZU;2-I
Abstract
Stereoselective ionic hydrogenation of vinblastine, anhydrovinblastine and vinorelbine in HF/SbF5 by methylcyclopentane yields the correspon ding 4'R reduced analogs. Deuterium labelling shows that the reduction occurs at C-20'. (C) 1998 Elsevier Science Ltd. All rights reserved.