EFFICIENT SYNTHESIS OF THIOETHER-BASED CYCLIC PEPTIDE LIBRARIES

Authors
ROBERTS KD LAMBERT JN EDE NJ BRAY AM
Citation
Kd. Roberts et al., EFFICIENT SYNTHESIS OF THIOETHER-BASED CYCLIC PEPTIDE LIBRARIES, Tetrahedron letters, 39(45), 1998, pp. 8357-8360
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
45
Year of publication
1998
Pages
8357 - 8360
Database
ISI
SICI code
0040-4039(1998)39:45<8357:ESOTCP>2.0.ZU;2-U
Abstract
A new method for the synthesis of cyclic peptide libraries has been de veloped where the key cyclisation step involves reaction between a C-t erminal cysteine side chain and an N-terminal bromoacyl group. We repo rt conditions whereby liberation of peptides from the solid support an d cyclisation occur concurrently to form thioether-linked cyclic pepti des in generally >95% yield. (C) 1998 Elsevier Science Ltd. All rights reserved.