HETEROCYCLIC-SYSTEMS CONTAINING BRIDGEHEAD NITROGEN ATOM - SYNTHESIS,STEREOCHEMISTRY AND BIOACTIVITY OF TRANS-8,8A-DIHYDRO-(4H)-[2H]-PYRAZOLO[3',4' 4,5]THIAZOLO[3,2-B]-S-TETRAZINES/

Authors
MOHAN J
Citation
J. Mohan, HETEROCYCLIC-SYSTEMS CONTAINING BRIDGEHEAD NITROGEN ATOM - SYNTHESIS,STEREOCHEMISTRY AND BIOACTIVITY OF TRANS-8,8A-DIHYDRO-(4H)-[2H]-PYRAZOLO[3',4' 4,5]THIAZOLO[3,2-B]-S-TETRAZINES/, Indian Journal of Heterocyclic Chemistry, 8(1), 1998, pp. 7-10
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian Journal of Heterocyclic Chemistry → ACNP
ISSN journal
09711627
Volume
8
Issue
1
Year of publication
1998
Pages
7 - 10
Database
ISI
SICI code
0971-1627(1998)8:1<7:HCBNA->2.0.ZU;2-D
Abstract
yl-(4H)-[2H]thiazolo[3,2-b]-s-tetrazine-6(7H)-ones (2) have been synth esized in a single step by condensation of 6,6-diethyl-1,2,4,5-tetrahy dro-s-tetrazin-3-thione (1) with ethyl chloroacetate and aldehydes in presence of pyridine and piperidine. Condensation of 2 with arylhydraz ines in presence of anhyd sodium acetate furnished ryl-trans-8,8a-dihy dro(4H)-[2H]pyrazolo[3',4':4,5] thiazolo [3,2-b]-s-tetrazines (3). The antibacterial and antifungal activity of some of the compounds have b een evaluated.