SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 7-ACETYL-2-CARBOXY-3,6-DIMETHYLFURO [2,3-F] INDOLES

Authors
GADAGINAMATH GS KAVALI RR
Citation
Gs. Gadaginamath et Rr. Kavali, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 7-ACETYL-2-CARBOXY-3,6-DIMETHYLFURO [2,3-F] INDOLES, Indian Journal of Heterocyclic Chemistry, 8(1), 1998, pp. 39-42
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian Journal of Heterocyclic Chemistry → ACNP
ISSN journal
09711627
Volume
8
Issue
1
Year of publication
1998
Pages
39 - 42
Database
ISI
SICI code
0971-1627(1998)8:1<39:SAAAON>2.0.ZU;2-1
Abstract
Substituted 3,6-diacetyl-5-hydroxyindoles (2a-c) were prepared by subj ecting 3-acetyl-5-hydroxyindoles (1a-c) to regioselective Friedel Craf t's acetylation with CH3COCl and AlCl3 in nitrobenzene. These indoles (2a-c) were made to react with methyl chloroacetate and anhyd K2CO3 in dry acetone to afford the desired -diacetyl-5-methoxycarbonylmethoxy- 2-methylindoles (3a-c) which were cyclized with anhyd K2CO3 in refluxi ng ethanol to yield 7-acetyl-2-carboxy-3,6-dimethylfuro [2,3-f] indole derivatives (4a-c). All these new heterocycles were screened for thei r antibacterial and antifungal activities.