THE SPECIFIC DOPAMINE UPTAKE INHIBITOR GBR-12783 IMPROVES LEARNING OFINHIBITORY AVOIDANCE AND INCREASES HIPPOCAMPAL ACETYLCHOLINE-RELEASE

Authors
NAILBOUCHERIE K DOURMAP N JAFFARD R COSTENIN J
Citation
K. Nailboucherie et al., THE SPECIFIC DOPAMINE UPTAKE INHIBITOR GBR-12783 IMPROVES LEARNING OFINHIBITORY AVOIDANCE AND INCREASES HIPPOCAMPAL ACETYLCHOLINE-RELEASE, Cognitive brain research, 7(2), 1998, pp. 203-205
Citations number
16
Categorie Soggetti
Neurosciences,"Computer Science Artificial Intelligence
Journal title
Cognitive brain research → ACNP
ISSN journal
09266410
Volume
7
Issue
2
Year of publication
1998
Pages
203 - 205
Database
ISI
SICI code
0926-6410(1998)7:2<203:TSDUIG>2.0.ZU;2-H
Abstract
The specific dopamine uptake inhibitor, GBR 12783 was tested on the re tention performance of a one-trial passive avoidance test. For a moder ate electric shock intensity, GBR 12783 (10 mg/kg), injected before ac quisition session, improved retention performance. Scopolamine (0.125- 0.5 mg/kg) completely blocked the promnesic effect of GBR 12783. Moreo ver, GBR 12783 increased hippocampal acetylcholine release in vivo. Th ese data suggest that the promnesic effect of GBR 12783 is mediated by an increase in the septo-hippocampal cholinergic transmission. (C) 19 98 Elsevier Science B.V. All rights reserved.