Cw. Vonderlieth et al., LECTIN LIGANDS - NEW INSIGHTS INTO THEIR CONFORMATIONS AND THEIR DYNAMIC BEHAVIOR AND THE DISCOVERY OF CONFORMER SELECTION BY LECTINS, Acta anatomica, 161(1-4), 1998, pp. 91-109
The mysteries of the functions of complex glycoconjugates have enthral
led scientists over decades. Theoretical considerations have ascribed
an enormous capacity to store information to oligosaccharides, In the
interplay with lectins sugar-code words of complex carbohydrate struct
ures can be deciphered. To capitalize on knowledge about this type of
molecular recognition for rational marker/drug design, the intimate de
tails of the recognition process must be delineated, To this aim the r
equired approach is garnered from several fields, profiting from advan
ces primarily in X-ray crystallography, nuclear magnetic resonance spe
ctroscopy and computational calculations encompassing molecular mechan
ics, molecular dynamics and homology modeling. Collectively considered
, the results force us to jettison the preconception of a rigid ligand
structure. On the contrary, a carbohydrate ligand may move rather fre
ely between two or even more low-energy positions, affording the basis
for conformer selection by a lectin. By an exemplary illustration of
the interdisciplinary approach including up-to-date refinements in car
bohydrate modeling it is underscored why this combination is considere
d to show promise of fostering innovative strategies in rational marke
r/drug design.