Al. Chenine et al., PRIMARY INTESTINAL EPITHELIAL-CELLS CAN BE INFECTED WITH LABORATORY-ADAPTED STRAIN HIV TYPE-1 NDK BUT NOT WITH CLINICAL PRIMARY ISOLATES, AIDS research and human retroviruses, 14(14), 1998, pp. 1235-1238
Infectivities of HIV-1 primary isolates and laboratory-adapted strains
were compared in primary fetal enterocytes and the colonic epithelial
cell line HT29. Infection by two laboratory strains, HIV-1 NDK and HI
V-1 NDKA4, which were adapted on CEM and HT29 cells, respectively, pro
duced significant amounts of virus in both target cell systems. Intest
inal cells were resistant to infection with HIV-1 primary isolates reg
ardless of their genetic subtype or SI/NSI phenotype, Biological prope
rties of analyzed viruses rather than differences in cultivation syste
m seem to be responsible for differences between these in vitro and ex
vivo results.