LINKAGE DISEQUILIBRIUM MAPPING OF THE GENE FOR MARGARITA ISLAND ECTODERMAL DYSPLASIA (ED4) TO 11Q23

Authors
SUZUKI K BUSTOS T SPRITZ RA
Citation
K. Suzuki et al., LINKAGE DISEQUILIBRIUM MAPPING OF THE GENE FOR MARGARITA ISLAND ECTODERMAL DYSPLASIA (ED4) TO 11Q23, American journal of human genetics, 63(4), 1998, pp. 1102-1107
Citations number
16
Categorie Soggetti
Genetics & Heredity
Journal title
American journal of human genetics → ACNP
ISSN journal
00029297
Volume
63
Issue
4
Year of publication
1998
Pages
1102 - 1107
Database
ISI
SICI code
0002-9297(1998)63:4<1102:LDMOTG>2.0.ZU;2-1
Abstract
Margarita Island ectodermal dysplasia (ED4) is an autosomal recessive disorder characterized by unusual facies, dental anomalies, hypotricho sis, palmoplantar hyperkeratosis and onychodysplasia, syndactyly, and cleft lip/cleft palate. We have used an affected-only DNA-pooling stra tegy to carry out linkage disequilibrium mapping of the ED4 gene to 11 q23. Haplotype analysis of four complex Margarita Island ED4 families localized the ED4 gene to an similar to 1-2-Mb interval spanned by jus t two YACs.