DESCRIPTION OF A NEW DRB1-ASTERISK-11 ALLELE (DRB1-ASTERISK-1132)

We describe a new DRB111 allele which is similar to DRB1*11011 except at codon 74, where a GCG is changed for a GTG leading to an alanine/v aline substitution. This new allele was carried by a Caucasian patient suffering from rheumatoid arthritis and by her healthy daughter. The motif at codon 74 of the new DRB111 is not found in any other known D RB alleles, nor among the published DQA1, DQB1, DPA1 or DPB1 alleles, and therefore suggests a mechanism of point mutation.