AN ANNULATION ROUTE TO 1,4-DIMETHOXYNAPHTHALENES

Authors
MEHTA BK BARUN O ILA H JUNJAPPA H
Citation
Bk. Mehta et al., AN ANNULATION ROUTE TO 1,4-DIMETHOXYNAPHTHALENES, Synthesis, (10), 1998, pp. 1483-1486
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
10
Year of publication
1998
Pages
1483 - 1486
Database
ISI
SICI code
0039-7881(1998):10<1483:AART1>2.0.ZU;2-T
Abstract
An efficient regiocontrolled synthesis of substituted and annulated 1, 4-dimethoxynaphthalenes as precursors for 1,4-naphthoquinone systems h as been developed through naphthoannulation route by regioselective 1, 2-addition of 2,5-dimethoxybenzylmagnesium chloride to acyclic and cyc lic alpha-oxoketene dithioacetals and subsequent BF3. OEt2 assisted cy cloaromatization of the resulting alcohols.