IDENTICAL TWIN MARROW TRANSPLANTATION FOR VENOUS THROMBOSIS IN PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA - LONG-TERM COMPLETE REMISSION AS ASSESSED BY FLOW-CYTOMETRY

Paroxysmal nocturnal hemoglobinuria (PNH), an acquired clonal hematopo ietic disorder characterized by protean clinical manifestations, is as sociated with significant morbidity and mortality. We report a 24-year -old patient with PNH complicated by deep vein thrombosis who underwen t syngeneic bone marrow transplantation. No clinical symptomatology or stigmata of disease have recurred. Immunophenotyping of this patient over 12 years after her procedure revealed all peripheral circulating cells to express normal levels of CD59. Histocompatible marrow transpl antation remains the definitive method of treatment for PNH with moder n immunophenotyping capable of sensitive follow-up post-transplant.