TOLERANCE AND BACTERICIDAL ACTION OF N-CHLOROTAURINE IN A URINARY-TRACT INFECTION BY AN OMNIRESISTANT PSEUDOMONAS-AERUGINOSA

N-chlorotaurine, a weak antimicrobial oxidant produced by stimulated h uman leukocytes, was used to treat cystitis caused by an omniresistant Pseudomonas aeruginosa. A 21-year-old male patient was treated by rep eated daily lavages of the urinary bladder with an aqueous solution of 1% N-chlorotaurine for one month. N-chlorotaurine was well tolerated; no local or systemic side effects could be detected. Despite killing of >10(6) cfu/ml of bacteria within ten minutes in vitro and in vivo, it was not possible to eradicate the Pseudomonas infection obviously c aused by inflammation of the upper urinary tract and perpetuated by in travesical concrements. Nevertheless, in actually localized infection, treatment with N-chlorotaurine might be successful because of its suf ficient bactericidal action.