MONOAMINE-OXIDASE INHIBITORY CONSTITUENTS FROM ANIXIELLA-MICROPERTUSA

Authors
FUJIMOTO H SATOH Y YAMAGUCHI K YAMAZAKI M
Citation
H. Fujimoto et al., MONOAMINE-OXIDASE INHIBITORY CONSTITUENTS FROM ANIXIELLA-MICROPERTUSA, Chemical and Pharmaceutical Bulletin, 46(10), 1998, pp. 1506-1510
Citations number
15
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
10
Year of publication
1998
Pages
1506 - 1510
Database
ISI
SICI code
0009-2363(1998)46:10<1506:MICFA>2.0.ZU;2-G
Abstract
Two known naturally-occurring constituents, 1,7-dihydroxy-3-methylxant hone and emodin, were isolated from an Ascomycete Anixiella micropertu sa as inhibitors of mouse monoamine oxidase (MAO), together with four non-MAO inhibitory components, including two novel compounds. 1,7-Dihy droxy-3-methylxanthone and emodin inhibited MAO moderately, and IC50 v alues were calculated to be 2.06 x 10(-5) and 3.70 x 10(-5) M, respect ively.