Sj. Dalton et al., EXACERBATION OF ATOPIC-DERMATITIS AFTER BACILLUS-CALMETTE-GUERIN VACCINATION, Journal of the Royal Society of Medicine, 91(3), 1998, pp. 133-134
In two children with atopic dermatitis, routine vaccination with bacil
lus Calmette-Guerin (BCG) was followed by severe exacerbation of skin
disease. If the sequence is cause and effect, a possible mechanism is
stimulation of a Th2 lymphocyte cytokine profile by the vaccine, with
migration of activated lymphocytes to inflamed skin. In children with
active atopic dermatitis, BCG vaccination is best deferred until remis
sion.