EFFECTS OF CEFEPIME, CEFIXIME AND CEFTIBUTEN ON MURINE GUT COLONIZATION BY CANDIDA-ALBICANS

Crl:CD1(ICR) BR mice were fed chow containing Candida albicans or regu lar chow. Both groups were subsequently given either antibiotics or no rmal saline. Stool cultures were performed before, at the end of treat ment and I week after treatment, to determine the effect on the stool yeast concentration. Candida-colonized mice treated with cefepime, cef ixime or ceftibuten had higher (however not significantly) counts of t he yeast in their stools than control Candida-fed mice treated with sa line. A group of Candida-fed mice were treated with ceftriaxone, which is known to increase the yeast stool concentration significantly and served as positive control. Mice fed regular chow and treated with the study drugs or saline did not have any yeasts in their stools. Dissem ination of Candida did not occur.